Antibody sensed protein surface conformation
نویسندگان
چکیده
منابع مشابه
A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface
Dengue virus (DENV), which consists of four serotypes (DENV1-4), infects over 400 million people annually. Previous studies have indicated most human monoclonal antibodies (HMAbs) from dengue patients are cross-reactive and poorly neutralizing. Rare neutralizing HMAbs are usually serotype-specific and bind to quaternary structure-dependent epitopes. We determined the structure of DENV1 complexe...
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In this work, we propose a radical approach for exploring the space of all possible protein structures. We present techniques to explore the clash-free conformation space, which comprises all protein structures whose atoms are not in selfcollision. Unlike energy based methods, this approach allows efficient exploration and remains general – the benefits of characterization of the space apply to...
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Background & Objective: One of the most common diseases between zoonosis - especially in developing countries – is brucellosis. Identification of Brucella cell antigen combinations in terms of the amount and type of immune response in infected hosts, are important in vaccine design. 31kDa Brucella cell surface protein (BCSP31) is shared among all Brucellae. We aimed to define specific immune r...
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-The scaling theory of conformation of a weakly charged polyelectrolyte molecule attached onto a charged surface is developed. It is shown that the long-range interaction between charged monomer units and similary (or oppositely) charged surface provides
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ژورنال
عنوان ژورنال: Materials Today
سال: 2011
ISSN: 1369-7021
DOI: 10.1016/s1369-7021(11)70303-0